摘要
本实验动态观察了庆大霉素对胆红素结石兔模型的氧自由基、前列膜素Ｅ＿２及胆红素结石等的影响。发现肝组织部分氧自由基与前列腺素Ｅ＿２、胆红素结石成石程度等指标在治疗组均低于非治疗组，且其动态变化相似，并呈正相关关系。提示庆大霉素可能通过其抗菌作用减少了白细胞产生氧自由基，致前列腺素Ｆ＿２生成减少，降低了粘（糖）蛋白的分泌，最终导致了胆红素结石生成减少。
The alterations of pigment gallstone, oxygen free radical and prostaglandin E_2 were studied in The rabbit models under the treatment of gentamycin. In gentamycin therapy group these variables were lower than those in the nontherapy group. It was suggested that gentamycin therapy might decrease the pigment gallstone formation by reducing the production of oxygen free radicals, prostaglandin E_2 and glycoprotein in rabbit models.
出处
《华西医学》
CAS
北大核心
1994年第3期347-349,共3页
West China Medical Journal
关键词
自由基
前列腺素
胆结石
Gailstones
Free radicals
Prostaglandin
Gentamycin.
