磺溴酞和酚磺酞在猪兔鸡的比较药动学研究

COMPARATIVE PHARMACOKINETICS OF BROMSULPHALEIN AND PHENOLSULFONPHTHALEIN IN SWINE,RABBITS AND CHICKENS

磺溴酞（ＢＳＰ，１５ｍｇ／ｋｇ）和酚磺酞（ＰＳＰ，３ｍｇ／ｋｇ）静注后在猪均具中等分布容积和高清除率特征，在兔呈高分布容积和中清除率特征，在鸡则是低分布容积和低清除率。３种动物比较，猪对两药的消除能力最强，兔体内易于药物分布，鸡对药物的消除和分布均相对较弱。两药在同种动物体内的分布动力学无显著差异，但ＢＳＰ的消除速度和程度比ＰＳＰ大。结果说明，动物种属是决定药物体内过程的首要因素，药物的结构及消除方式是其次。在药物的使用、研制和评价过程中应对药动学种属差异的特性予以充分注意。

Pharmacokinetics of bromsulphalein(15 mg·kg-1) and phenolsulfonphthalein(3 mg·kg-1) administered simultaneously by an intravenous bolus injection to swine (n=6), rabbits(6) and chickens(6)were investigated. Concentrations of the drugs in plasma were assayed by spectrophotometry. The experiments showed that both drugs had a medium distribution volume and a greatest clearance in swine, a highest distribution volume and a medium clearance in rabbits, and a lowest distribution volume and a smallest clearance in chickens. Swine possessed a stronger ability to eliminate the drugs. Rabbits facilitated the drugs to distribute in the body. However, chickens had a weaker capacity to make the drugs eliminating and distributing. BSP had a more fast rate and a greater extent of elimination from the body than PSP had although there was not a statistically significant difference of the distribution kinetics between both drugs. The results suggest that animal species is the first, and the chemical structure of drugs is the second factor among those which effect disposition of drugs. Pharmacologists and veterinarians,therefore, must pay a great attention to the species differences when developing, evaluating and utiliging drugs.