香芹酮的双重Michael反应和在天然产物手性合成中的应用

Double Michael Reaction of Carvone and Its Utilization in Chiral Synthesis of Natural Products

香芹酮与α,β-不饱和酯顺利进行双重Michael加成反应,所得光学活性的[2.2.2]桥环化合物为一些天然产物的手性合成提供了十分有用的中间体.本文报道了这两方面的研究进展.

The double Michael reaction of carvone and methyl methacrylate was described in detail. Its product, an optically active bicyclo [2.2.2]octane derivative, is a useful intermediate for the chiral synthesis of natural products. In this respect an elemene derivative and an intermediate for the synthesis of (+)-curdione were synthesized.