紫外线照射与照射后抗佝偻病作用的时间－效应关系的实验研究

A Laboratory Study of Time-Effect Relationship of Ultraviolet Radiation on Rickets Curation after UVR

本文探讨大鼠长期受小剂量紫外线照射及照射后其抗佝偻病作用的时间效应关系。结果表明：各剂量组血清２５羟基维生素Ｄ_３衰减呈对数方式，有明显的时间效应关系。１／８ＭＥＤ组衰减最快，停照１２周时已出现维生素Ｄ异常，３６％骨化异常；１／４ＭＥＤ组衰减最慢，停照１２周时可处于正常水平；１／２ＭＥＤ组效应低于１／４ＭＥＤ组，表明１／４ＭＥＤ剂量是合成维生素Ｄ的最佳剂量，过量紫外线照射无增强作用。提示人体夏秋季日照射１／４ＭＥＤ，即使冬季无照射，贮存的维生素Ｄ可维持血液维生素Ｄ水平正常至冬季，预防佝偻病的发生。

In this paper,after radiating rats with different small dose ultraviolet light for l2 weeks,we imitated an nonshine exposure for a season,observing the situation of serum 25-OHD3,chemical index and ossify,discussed the relationship between U V R and rickets curation.The results showed that every group had distinct time-effects relationship.On the time of ceasing U V R 12 weeks,vitamin D difficiency occured in l/8MED group; l/4MED and l/2M ED groups had no vitamin D dificiency.1/4MED is best dose to synthetize vitamin D.It is suggested that person exposing to sunshine l/4MED per day in summer and autumn can maintain vitamin D without rickets in whole winter even no erythermal U V R can be obtained.