表皮生长因子与生长抑素对人离体胎盘分泌hCG的影响

Effect of Epidermal Growth Factor and Somatostatin on Secretion of hCG in Human Placenta Villi in Vitro

本工作利用灌流技术，观察了不同浓度的表皮生长因子（ＥＧＦ）（２５、５０、１００、５００ｎｇ／ｍｌ）和生长抑素（ＳＲＩＦ）对妊娠早期人工流产新鲜胎盘绒毛分泌人绒毛膜促性腺激素（ｈＣＧ）的影响．结果表明，ＥＧＦ对人早期胎盘ｈＣＧ的分泌有双向作用，５０ｎｇ对ｈＣＧ分泌刺激作用最大，５００ｎｇ则抑制ｈＣＧ的分泌。生长抑素单独使用不影响ｈＣＧ分泌，但可抑制ＥＧＦ诱导的ｈＣＧ分泌。提示ＥＧＦ、ＳＲＩＦ可能参与ｈＣＧ的分泌调节。

sing perfusion technique,the effects of Epidermal Growth factor(EGF)and Somatostatin(SPIF)on Human Chorionic Gonadotropin(hCG)secretion of Pla-centa at 45～55 days of pregnency were observed in vitro.EGF plays a dual rolein hCG secretion.EGF at the concentration of 50ng/ml stimulated hCG secretion signi-ficantly.EGF secretion was inhibited by the highest dose(500ng/ml) f EGF.However,SRIF had no effect on basal hCG secretion in chorion perfusion. We observedfirst that SRIF inhibited increase of hCG induced by EGF.EGF and SRIP mayplay important roles in the regulation of hCG secretion.