甲基丙烯酸环氧丙酯致癌性的研究

Studies on Carcinogenesis Induced by Glycidy1 Methacrylate

转化试验和裸鼠接种诱癌试验结果表明：环境诱变剂ＧＭＡ能诱发ＢＡＬＢ／ｃ３Ｔ３细胞发生明显的形态学转化作用，当细胞培养中ＧＭＡ浓度为４μｇ／ｍｌ时，转化率与阳性对照（ＭＣＡ浓度为２．５μｇ／ｍｌ）相近，且具有剂量—效应关系；用经分离、鉴定得到的转化细胞接种裸鼠背、腋皮下部位，２２ｄ后局部出现肿块，经病理检查均为纤维肉瘤，从而在细胞和整体水平上证明ＧＭＡ具有致癌性。

ALB/c 3T3 cells as target cells in vitro and nude mice as target animal invivo have been tested for cell malignant transformation and tumor formation induc-ed by GMA,respectively.After exposure to well-known carcinogen MGA with finalconcentration of 2.5μg/ml and new mutagen GMA with 1～8μg/ml,typical morpholo-gical transformation in both treated cells was observed.In vitro experimental resultshowed a relationship of dose-response.In 100%of nude mice inoculated withtransformated cells in 22 days tumors were seen and identified as fibrosarcoma bypathological histology.