摘要
观察了经调理的酵母多糖(OZ)、N-formylmethionyl-Lencyl-pbenylalanine(fMLP),Calciuminophore(A23187).等几种白细胞激动剂引起的大鼠腹腔中性粒细胞(PMNs)的化学发光和次黄嘌呤-黄嘌呤氧化酶系统(HO-XO)产生的化学发光.观察到了具 有抗炎作用的中药单体764-3对PMN吞噬OZ引起的化学发光及HO-XO系统产主的化学发光具有明 显的抑制作用。
hemiluminescence(CL)were produced by stimulation of polymorphonuclear leukocytes(PMNs)with opsonized-zymosan(OZ),fMLP,A23187 and hypoxanthin-xan- thinoxidase(HO-XO)systeme in vitro,The inhibition of 764-3 on CL was stud- ied. The results showed that 764-3,an effective antiinflammatory drug extracted from chinese herb ,could inhibit both CL induced by PMNs phagocytosis of OZ .Ho-Xo,The possible mechanism of 764-3 effect was discussed.
出处
《基础医学与临床》
CSCD
1994年第6期55-57,共3页
Basic and Clinical Medicine
关键词
化学发光
丹参提取物
氧自由基
抑制
Chemiluminescence(CL )764-3 neutrophil(PMNs)opsonized-zymosan (OZ)