丹参提取物对氧自由基引起的化学发光的抑制作用

The Inhibition of Extracts of Radix Saliva Miltiorrhiza on Oxygen Free Radical Induced Chemiluminescence

观察了经调理的酵母多糖（ＯＺ）、Ｎ－ｆｏｒｍｙｌｍｅｔｈｉｏｎｙｌ－Ｌｅｎｃｙｌ－ｐｂｅｎｙｌａｌａｎｉｎｅ（ｆＭＬＰ），Ｃａｌｃｉｕｍｉｎｏｐｈｏｒｅ（Ａ２３１８７）．等几种白细胞激动剂引起的大鼠腹腔中性粒细胞（ＰＭＮｓ）的化学发光和次黄嘌呤－黄嘌呤氧化酶系统（ＨＯ－ＸＯ）产生的化学发光．观察到了具 有抗炎作用的中药单体７６４－３对ＰＭＮ吞噬ＯＺ引起的化学发光及ＨＯ－ＸＯ系统产主的化学发光具有明 显的抑制作用。

hemiluminescence(CL)were produced by stimulation of polymorphonuclear leukocytes(PMNs)with opsonized-zymosan(OZ),fMLP,A23187 and hypoxanthin-xan- thinoxidase(HO-XO)systeme in vitro,The inhibition of 764-3 on CL was stud- ied. The results showed that 764-3,an effective antiinflammatory drug extracted from chinese herb ,could inhibit both CL induced by PMNs phagocytosis of OZ .Ho-Xo,The possible mechanism of 764-3 effect was discussed.