人早孕蜕膜组织中神经递质与神经肽含量的研究

Studies on the Neurotransmitters and Neuropeptides of Decidua in the Human Early Pregnancy

于吸刮术时收集月经周期增殖期和分泌期的子宫内膜组织及妊娠6～11周的新鲜壁蜕膜组织。用高压液相色谱-电化学检测及放射免疫法对38例子宫内膜及70例早孕壁蜕膜组织中的各种神经递质、神经肽含量进行测定。证实早孕蜕膜组织富含神经递质、神经肽。其中DA、DOPAC显著高于子宫内膜中的量(P<0.05),且随妊娠时间的延长含量逐渐升高,β-EP及LH-RH的含量也显著高于子宫内膜组织(p<0.05),但随妊娠时间的延长含量逐渐下降。这一初步结果表明蜕膜组织可以合成神经递质、神经肽,其意义有待进一步深入研究。

Fresh human endometrium in the follicular and luteal phases of the menstrual cycle and wall decidual tissues at 6-11 weeks of gestation were collected by suction curettage. Content of the different kindes of neurotransmitters and neuropeptides in the endometrial and decidual tissues were tested using HPLC technique and RIA, respectively. It was found that the contents of neurotransmitters and neuropeptides in the decidua were very abandant, and DA, DOPAC. β- EP and LH-RH of them in the decidua appeared significantly higher than those in the endometrium (P<0.05). The contents of DA and DOPAC in the decidua increased gradually with the prolongation of the gestation weeks (p<0.05). On the contrary,β-EP and LH-RH showed decrease (p<0.05). These preliminary results suggest that the decidua synthesizes not only β-EP, LH-RH, but also neurotransmitters. The significance of these finidings is of interest and needs further clarifying