人乳头瘤病毒形态发生学的初步探讨

A Early Study about Morphogenesis of Human Papillomavirus

利用透射电镜对11例寻常疣和2例蹠疣的超微病理进行了研究,并用免疫组织化学染色的方法对HPV抗原进行了定位,结果显示在表皮的基底细胞层和棘细胞中下层中,未发现病毒颗粒和病毒抗原,病毒颗粒和抗原主要存在于颗粒层的细胞核内及角化层,有时在棘细胞上层的细胞核内也可见到。此外,在棘细胞上层细胞核内可见到一些“前病毒颗粒”。

Ultrastructure of eleven common warts and two plantar warts were studied by transmitional electron microscopy. HPV antigens were localizied by immunohistochemical staining. Results showed that there was no viral particals or antigen in the stratum basale and lower or middle stratum spinosum. The viruses and antigens were mainly found in stratum granulosum and corneum, sometimes in upper stratum spinusum. 'Pre-virus particlesn' were seen in upper stratum spinusum. A morphogenetic course of HPV in squamous epithelial cells was discovered.