摘要
以邻二氯苯为起始原料,经硝比、醚化、还原、卤化、缩会等五步反应(总收率约46%),合成了抗肝片吸虫新药碘醚柳胺,并以红外光谱、质谱和元素分析等对此化学结构进行了确证。
Rafoxanide or Flukanide, the new anti-fascioliasisdrug, was firstly sythesised in our country from 1, 2-dicholobenzenevia nitration, etherification, reduction, halogenation and condensa-tion steps, the overall yield was about 46%. The structure wasproven by IR, MS and elementary analysis.
关键词
碘醚柳胺
肝片吸虫病
兽医药
制备
synthesis of Rafoxanide
IR
MS
elementary analysis