慢性肾炎肾盂肾炎患者血清LPO　SOD检测的临床意义

MEASUREMENT OF LPO AND SOD IN THE SERUM OF CHRONIC NEPHRITIC OR PYELONEPHRITIC PATIENTS

本文检测了５２例慢性肾炎、１６例肾盂肾炎患者血清中脂质过氧化物（ＬＰＯ）的含量和血清超氧化物歧化酶（ＳＯＤ）活力。结果发现：慢性肾炎组、肾盂肾炎组血清ＬＰＯ含量较正常对照组显著升高（Ｐ＜０．０１）、血清ＳＯＤ活力却明显下降（慢性肾炎组Ｐ＜０．０１、肾盂肾炎组（Ｐ＜０．０５），两病组相比较，慢性肾炎组血清ＬＰＯ高于肾盂肾炎组（Ｐ＜０．０１）血清ＳＯＤ低于肾盂肾炎组（Ｐ＜０．０５），提示肾脏的损伤与自由基有关且慢性肾炎患者更严重。血清ＬＰＯＳＯＤ检测有助于慢性肾炎、肾盂肾炎的诊断、治疗和预后估计。

The contents of lipid peroxides(LPO) and the activty of superoxide dismutase(SOD) in the serum of 52 patients with chronic nephritis and 16 patients with pyelonephritis were measured.The results revealed that the contents of LPO were significantly higher in the patients than in healthy controls (P<0.01),but the activity of SOD was markedly lower.At the same time,our data further indicated that LPO in the patrents with chronic nephritis was higher as compared with that in the patients with pyelonephritis (P<0.01),but the activity of SOD in the patients with chronic nephritis was lower (P<0.05).These findings suggest that kindney injury is related to the free radicals in the patients with chronic nephritis and patients with pyelonephritis,but more significantly with the former.