均匀设计及其在鸟嘌呤核苷酰化反应中的应用

UNIFORM DESGIN AND ITS APPLICATION IN ACYLATION REACTION OF GUANOSINE

鸟嘌呤核苷经酰化，酰解反应制得二乙酰鸟嘌呤和四乙酰核糖。本文用均匀设计及逐步回归分析寻找酰化反应的最佳条件，使二乙酰鸟嘌呤和四乙酰核糖的收率分别为９０．３２％和５９．６３％。

N￣2-aretylguanine and tetracetyl-β-D-ribofuranose were prepared by guanosine through arylation, arylolysis.Searched the best condition of acylation reaction with Uniform Design and Analysis of Stepwise Regression. Yield of N￣2-acetylguanine and tetracetyl-β-D-ribofuranose were 90.32% and 59.63%.