巨细胞病毒感染对染色体畸变率的影响

The influence of cytomegalovirus infection on chromosomal aberration

用 CMV 包涵体法确定个体 CMV 感染,分别在人类生命期的三个不同阶段设CMV 感染阳性和阴性比较组,胚胎期以胚胎绒毛组织滋养层细胞染色体为观察指标;新生儿期和成年人期以外周血淋巴细胞染色体为观察指标,发现胚胎绒毛组织染色体 CA 率在CMV 感染阳性组显著高于阴性组(P<0.01),而在新生儿期和成年人期的外周血染色体 CA率检测中,CMV 阳性组和阴性组比较未发现显著差异。

CMV infections were decided by cytomegalic inclusion method.The contrasts between CMV infection positive group and negative group were made in three different stages of hu- man life.The fetus stage use the fetal villus tissue chromosomes as observation targat,the offspring and adult stags use the peripheral blood lymphocyte chromosomes as observation target'.It was found that the chromosomal aberration frequencies of fetal villus tissue in the CMV infection positive group was higher significantly than the negative group(P<0.01). But in the study on the peripheral blood lymphocyte chromosomes offspring and adult stages,no significant differences were found between CMV infection positive and negative (?)