鸡马立克氏病二价苗对超强毒攻击的保护试验

PROTECTIVE EFFICACY OF THE BIV ALENT VACCINEAGAINST VERY VIRULENT MAREK'SDISEASE VIRUS STRAIN

将鸡马立克氏病毒（ＭＤＶ）血清Ⅱ型Ｚ_４毒株５００个空斑形成单位（ＰＦＵ）与ＭＤＶ血清Ⅲ型ＦＣ_（１２６）毒株１０００ＰＦＵ组成鸡马立克氏病（ＭＤ）二价疫苗，免疫对ＭＤ高度易感的Ｐ系ＳＰＦ白来航鸡，设３０１Ｂ／１＋ＦＣ＿（１２６）二价疫苗，Ｚ＿４，３０１Ｂ／１和ＦＣ_（１２６）３种单价疫苗免疫组做对照，以ＭＤＶ超强毒Ｍｄ＿５毒株（ｖｖＭＤＶ－Ｍｄ_５）攻击。结果表明：Ｚ_４＋ＦＣ_（１２６）和３０１Ｂ／１＋ＦＣ_（１２６）２种二价疫苗均能给免疫鸡提供较强的免疫效力，而３种单价疫苗则不能给免疫鸡提供对ｖｖＭＤＶ－Ｍｄ＿５毒株攻击的有效保护力。

The protectivc cfficacy of the bivalcnt vaccine containing 500 PFU Z_4 and 1000 PFU FC_(126) was assaycd in P line(B19/B19)SPF Whitc Lcghorn chickcns which arc highly susccptivc toMarek's discase.The result showed that the bivalent vaccine containing Z_4+FC_(126) could give effectiveprotective potency to the chickens challcnged with very virulent Marek's disease virus Md_5 strain(vvMDV-Md_5),and there were no obvirous diffcrcnce between the bivalent vaccine including Z_4+FC_(126)and 301 B / 1+ FC_(126) with rcspect to their protective potencies. But monovalent vaccines including Z_4,301B / 1 and FC_(126) vaccine could not effectively protect chickens from challcnge of vvMDV-Md_5。