流行性出血热若干体液因子和肾脏血液动力学的变化

Changes of Several Humoral Factors and Renal Hemodynamics in Epidemic Hemorrhagic Fever

对28例流行性出血热（EHF）患者作了体液因子和肾脏血液动力学的观察研究。发现患者从发热期至多尿初期血浆内皮素（ET）、血栓素B2（TXB2）、血管紧张素-Ⅱ（AT－Ⅱ）均高于正常，P物质（SP）则低于正常，6-酮前列腺素F1α（6-k-PGF1α）除极期外其它各期亦见减低，肾小球滤过率（GFR）与肾有效血浆流量（ERPF）从发热后期至多尿期均显著下降，至恢复初期多数重型患者仍未达到正常。上述结果提示体液因子的失衡是造成内脏缺血和急性肾衰的重要因素。

Some changes of humoral factors and renal hemodynamics were studied in 28 cases of epidemic hemorrhagic fever (EHF). Plasma endothelin (ET), Substance P (SP), thromboxane B2 (TXB2 ), 6-keto-prostaglandin F1α (6-K-PGF1α) and angiotensin- Ⅱ (AT-Ⅱ) were detected with radioimmunoassay (RIA) method,and glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) assessed with emission computerizedtomograghy(ECT). The results showed that in the first three phases of EHF the c0ncentrations of plasma ET,TXB, and AT-Ⅱ were much higher than normal level, plasma SP and 6-K-PGF1α were lower than normal valueexcept hypotensive-oliguric stage, that GFR and ERPF were strikingly decreased until polyuric or recovery stages.These results suggested that the imbalance of humoral factors might be an important factor responsible for visceralischemia and acute renal failure,and the antagonists of vasoconstrictors might be beneficial to circulatory recovery.