幽门螺杆菌与胃癌及胃异型增生

Helicobacter Pyloridis in Gastric Cancer and Dysplasia of the Stomach

对102例胃癌及35例胃异型增生的活检标本进行了光镜及电镜观察，其幽门螺杆菌（HP）检出率分别为52．94％、62．86％，与对照组22．0％比较，P＜0．01。癌旁活动性胃炎的HP检出率明显高于非活动性胃炎，P＜0．01。萎缩性胃炎HP检出率高于浅表性胃炎，0．01＜P＜0．05。结果表明，HP的阳性率与癌旁慢性胃炎的严重程度及活动性密切相关，推论HP对慢性胃炎的发展起加速作用。因此，控制HP感染对阻断和延长慢性胃炎癌变的发生有重要意义。

Gastric biopsies from 102 cases of gastric cancer and 35 cases of gastric dysplasia were studied by light microscopy and electron microscopy. The infection rate of Helicobacter Pyloridis (HP ) in gastric cancer was 62. 86% and that in gastric dysplasia was 52. 94%. In the mucosa adjacent to the turnour, HP was found in 71. 67％of cases with active chronic gastritis, and only 26. 19 % in those cases with inactive chronic gastritis. The result indicates that there is a close correlation between HP infection and periturnoral active atrophic gastritis. Thereforc,it is very important to control the HP infection and advancement of activity in chronic gastritis for the sake of decrease of the incidence of gastric cancer, as its precusor factors are avoided.