内毒素血症中降钙素基因相关肽的变化及其对血流动力学的影响

CHANGES IN PLASMA CALCITONIN GENE-RELATED PEPTIDE AND ITS EFFECTON HEMODYNAMICS IN ENDOTOXINEMIA

观察了内毒素血症时血浆降钙素基因相关肽（ＣＧＲＰ）的变化及其与血流动力学改变的关系。结果表明，用辣椒素抑制ＣＧＲＰ再注射内毒素时，血浆ＣＧＲＰ的释放量仅为内毒素血症对照组的３９．１％，同时动物的平均动脉压（ＭＡＰ）、中心静脉压（ＣＶＰ）和总末梢阻力（ＴＰＲ）的降低幅度明显减少（分别为８７．５０±６．５７，３．８７±０．８８，３．０４±０．２７ｋＰａ）。当再次注射ＣＧＲＰ时，随着血浆ＣＧＲＰ含量的增加，ＭＡＰ、ＣＶＰ和ＴＰＲ又明显降低（分别６３．７５±５．１８，０．６０±１．５３，２．２８±０．２８ｋＰａ）。３组动物的血浆ＣＧＲＰ变化差值与ＭＡＰ的变化差值呈显著的负相关（分别为ｒ＝－０．８３９０，ｒ＝－０．８３６８，ｒ＝－０．９５６４；Ｐ＜０．０５，０．０５，０．０１），但与ＣＯ的变化差值无相关（分别ｒ＝０．３７５１，ｒ＝－０．２５７８，ｒ＝０．２２５８；Ｐ＞０．０５）。提示内毒素血症ＣＧＲＰ直接参与对血流动力学改变的作用，但并不直接影响心肌功能的改变。

We studied both the changes in plasma calcitonin gene-redlated peptide (CGRP) and therelation between plasma CGRP and changes in hemodynamics in rat endotoxinemia. It was found that thequantity of CGRP released by LPS was only 39. 1% of control endotoxinemia group , when CGRP was in-hibited precedently by capsaicin, and meanwhile, the range of depression of mean arterial pressure(MAPi , central venous pressure (CVP) and total peripheral resistance (TPR) was abated significantly(87.50±6.57, 3. 87±0. 88, 3. 04±0. 27kPa , respectively3. When CGRP was given again , the level ofMAP, CVP and TPR dropped significantly (63. 75±5. 18, 0. 60±1. 53, 2. 28±0. 28kPa , respectively)following the increasing levels of plasma CGRP. A negative correlation was found between the differencevalues of plasma CGRP and that of MAP (r=0. 8390, r=0. 8368, r=-0. 9564;P<0.05 , <0. 05,<0. 01 , respectively),whereas a correlation was not found between the difference value of plasma CGRPand that of CO (r= 0. 3751 , r=-0.2578, r=0. 2258;P>0. 05 respectivelyi in three groups. We con-clude that plasma CGRP exerts direct effect on hemodynamics out it shows on direct influence on myocar-diac function in endotoxinemia.