我国首例异体小肠移植成功的临床经验

CLINICAL EXPERIENCE OF SUCCESSFUL ALLOTRANSPLANTATION OF SMALL INTESTINE FOR THE FIRST CASE IN OUR CONTRY

报告国内临床首例异体全小肠移植获得成功。病人女性，３１岁，１９７５～１９９３年先后施行９次腥部手术。因慢性小肠结肠炎，反复肠梗阻、短肠综合征，于１９９４年３月１２日接受小肠移植。供肠长２５０ｃｍ，热缺血６ｍｉｎ，冷缺血９．４５ｈ，行一期原位移植。免疫抑制方案为环孢素Ａ、雷公藤、甲基强的松龙联合用药。病人术后已１３０ｄ，经过顺利，移植肠功能在恢复中。作者结合本例成功的初步经验，讨论了小肠移植的免疫抑制和感染防治。

Successful allotransplantation of small intestine for the first case is reported in this paper The patient was a 31 years old female, who had been operated on abdomen for 9 times, She underwent al-lotransplantation of smallintestine in March 12, 1994 due to chronic enterocolitis, repeated intestinal ob-struction, and short bowel syndrome. The primary in situ transplantation was performed with its intes-tine for grafting 250cm, warm ischemia for 6 minutes and cold ischemia for 9. 45 hours, Cyclosporin, tripterygium wilfordii, and methylprednisolone were combinedly used for prevention of immunosup- pression。 The function ofthe transplanted small intestine is recovering。 Prevention and treatment of its immunosuppression and infection were also discussed