北京男性青年1991～1992年四季血清流感血抑抗体水平的分析研究

SURVEILLANCE OF THE LEVEL OF INFLUENZA VIRUS ANTIBODY FOR YOUTH IN BEIJING IN FOUR SEASONS

作者于１９９１年４、８、１１月和１９９２年２月在北京市北、东南和南３个部队营区共采集１２７９例血清，以当前国家流行的流感病毒株Ａ／京防／１／８６（Ｈ＿１Ｎ＿１），Ａ／济防／１５／９０（Ｈ＿３Ｎ＿２），Ｂ／沪防／２４／８８为抗原，检测血凝抑制杭体。人群对甲＿１抗体阳性率最高≥１：１０者８３％，ＧＭＴ（几何平均滴度）为３８．１。对甲＿３抗体次之，抗体阳性卒为５９％，ＧＭＴ２４．９。人群对乙型抗体最低，抗体阳性率为５６％，ＧＭＴ２１。从人群抗体春、夏、秋、冬四季结果分析，流感３个亚型抗体在春和秋分别出现高峰；甲＿１抗体以春季升高明显；甲＿３抗体以春、秋均升高明显；乙型抗体则以秋季升高明显。作者对１２７９例人群的呼吸道感染发病率作了统计；总发病率为５８％（７３６／１２７９），以冬季发病５３％（３９３／７３６）和夏季３０％（２２４／７３６）为高峰。

nfluenza virus, as a pathogen, is characterized by its antigenic drift,which enables itself with high infectivity. The levels of antibody againstinfluenza virus are an important factor for prophylaxis and treatment ofinfluenza. In four seasons from spring of 1991 to winter of 1992, total 1279serum samples were collected from young men 18-25 years old in Beijingarea. All of the samples were tested for hemagglutinin inhibition antibody(HIAb) by using antigens of influenza virus-A/Beijing/1/86(H_1N_1),A/Jinan/15/90(H_3N_2)and B/Shanghai/24/88. The results showed that the positiverates of HIAb against A_1, A_3 and B(HIAbA_1,A_3,B)were 83%, 59%and56%,and the GMT (Geometric Mean Titer) 38.1, 24.9 and 21,respectively.These three antibodies came up to peak titer in spring and fall: the peaktime of HIAbA_1 was in spring, HIAbA_3 in spring and fall and HIAbB infall. In addition, we surveyed the morbidity of respiratory infectiolis disea-ses of the 1279 young men. The disease incidence was 58%(736/1279) andthe peak morbidity was 53%(393/736)in winter and 30%(224/736) in su-mmer. The surveillance indicated that there are cases infected by influenzavirus A_1,A_3 and B through over the year, but mainly in winter and summ-er.