摘要
采用放射自显影技术观察了 ̄3H标记5-氟脲嘧啶( ̄3H~5FU)微球静脉注射后不同时间在小鼠肺中的分布和变化。并且对注射 ̄3H-5FU微球和 ̄3H-5FU溶液后的某些器官组织中放射性的分布进行了比较。提出微球在体内的直径为5-15μm,主要集中在肺组织中,可以达到位控给药的目的。在注射微球制剂2─24h肺中药物浓度明显维持较高水平。这对于延长和提高5FU对肺部肿瘤的疗效可能具有重要的意义。
Microspheres containing tritiated 5FU are injected into mice. The mice were killed in different time afterinjection,and the distribution of the microspheres in lung was measured autoradiographically.The distribution ofradioactivity in several other organs was also detected after iv injection of microspheres.The results showed thatthe diameter of microspheres was about 15 micron in vivo。The 5FU microspheres mainly accumulate in lung andthey maintain a higher level of 5FU concentration 2 to 24 hours after iv injection. The microspheres may be usedas a carrier of 5FU,to prolong the therapeutic effect in the treatment of lung cancer.
出处
《军事医学科学院院刊》
CSCD
北大核心
1994年第1期30-32,共3页
Bulletin of the Academy of Military Medical Sciences
关键词
5-氟脲咪啶
微球
放射自显影
银粒
microspheres of tritiated 5FU
autoradiograph
silver grains