维生素D中毒对鼠髁突软骨发育的影响

Effect of vitamin D intoxication on development of condylar cartilage

作者应用光镜和体内３Ｈ—ＴｄＲ掺入实验，观察维生素Ｄ实验性中毒对鼠髁突软骨发育的影响。结果显示：维生素Ｄ中毒直接损害髁突软骨生发层，阻碍软骨细胞的ＤＮＡ合成，使髁突软骨层次减少，软骨层变薄。证实维生素Ｄ中毒可导致髁突软骨发育受限。

Abstract Microscopic technique and incorporating 3H -Tdr invitro were used to investigate the effect of vitaminD intoxication on developement of condylar cartilageof rats.the results showed that vitamin Ddestroyed the chondroprogentor layer,hinderedDNA synthesis of chondroagte,reduced the layersof condylar cartilage and made the whole layers ofcondylor cartilages thinner,the resultsdemonstrated that the confined development ofcondylar cartilage was major position damaged byvitamin D intoxication to mandibular.