银屑病患者易伴发心血管疾病的机制探讨──血脂、血浆血栓素B_2、6－酮－前列腺素F_（1α）和血小板聚集功能的研究

Pathogenesis of cardiovascular complication in psoriasis patient──Study on serum lipids,TXB_2, 6-keto-PGF_(1α)and platelet aggregation function

银屑病伴发心血管疾病者明显增多，为探讨其机制，对８２例银屑病患者作血脂检测，３３例作ＴＸＢ２、６－酮－ＰＧＦ１α和血小板聚集功能研究。结果部分患者血脂有不同程度的增高。ＴＸＢ２和６－酮－ＰＧＦ１α也均增高，尤以ＴＸＢ２为著，血小板聚集功能也明显增高。这些变化与病情活动、皮损范围及病程长短有一定关系。心血管疾病有同样的变化，提示有共同的病理生理学基础。根据这些变化对银屑病的发病以及易伴发心血管疾病的机理作了讨论。

In order to study the pathogenesis of frequent association of cardiovascular diseases in psoriatics,serum lipids were determined in 82 patients,and TXB2,6-keto-PGF1α and platelet aggregation function were examined in 33 patients.The results showed that serum lipids were increased in a part of patients.TXB2 and 6-keto-PGF1α levels were both markedly increased,especially TXB2;and there was also marked increase of platelet aggregation function.The aforementioned changes were correlated with the disease activity,extensiveness of skin lesions and duration of the illness.Similar changes were found in cardiovascular diseases,indicating that cardiovascular dieases and psoriasis both had the same pathophysiological changes.The role of these changes in the susceptibility of cardiovascular complication in psoriasis and in the pathogenesis of psoriasis itself is discussed.