胆脂瘤型中耳炎患者中耳肉芽肿的免疫组织化学观察

Immunohistochemistry observation of granuloma in human aural cholesteatoma

应用免疫组织化学研究方法观察分析了８例胆脂瘤型中耳炎患者中耳肉芽肿的细胞种类、分布，探讨它们在发病中的作用。发现在该肉芽肿的基本病理组织学构成体中存在着Ｔ细胞、Ｂ细胞、朗格罕细胞及ＨＬＡ－ＤＲ阳性细胞，其中Ｔ细胞数量明显多于Ｂ细胞，初步说明Ｔ细胞所形成的细胞免疫是本病免疫反应的中心。

Immunohistochemistry analysis of granulomas was performed in 8 patients who had aural cholesteatomas. The results showed that there were T lymphocytes, HLA-DR positive cells, langerhans cells and B lymphocyte in granulomas, Among them the numbers of T lymphocyte were apparently more than those of B lymphocyte. This preliminarily suggests that T lymphocyte play the most important role in immune reaction of the granuloma in aural cholesteatoma.