原发性中枢神经系统非何杰金淋巴瘤影像学特征

Image Feature of Primary Non-Hodgkin's Lymphoma in Central Nervous System

本文报告１５例原发性中抠神经系统非何杰金淋巴瘤并讨论该病的神经病理、影像学特征及其临床疗效。１５例患者中６例为多发病灶。肿瘤的ＣＴ表现多呈边界清晰、明显强化的分叶状病灶，并沿脑室广泛浸润。在本组经病理确诊的原发性中枢神经系统非何杰金淋巴瘤中，８例经免疫组化染色为Ｂ细胞型。肿瘤的ＰＣＮＡ－ＰＣ１０染色显示淋巴瘤细胞的增殖速率大于２４．８％，但临床上对放疗和化疗高度敏感。１５例患者中经首次放疗和化疗后有１３例病灶明显消退，其中８例存活期达２４月以上。予以足量放疗并尽可能重复化疗可使患者的生存期明显延长。

Fifteen patients of primary non-Hodgkin's lymphoma in central nervous system(PNHL-CNS)were reported and the correlatiOn among the image feature, neuropathological and clinical therapeutic were discussed.The tumors showed multifocal lesions in 6 of l 5 patients,CT examinations revealed that the tumors were most often demarcated,showing well contrast enhanced lesions and widespread infiltration around the ventricular wall.8 of 15 cases confirmed by pathological examinations showed all B cell type origin by immunohistochemical staining,The tumors highly responded to the radio-chemotherapy even though the high rate of proliferating cell ratio above 24.8%stained by PCNAPCI10.The lesions disappeared evidently after the initial treatment in 13 of 15 cases and 8 cases survived beyond 24 months,It offers long survivals to the patients to give full dosage of radiotherapy and repeat chemotherapies as possible.