异丙酚诱导期脑电效应

The Effect of Propofol on EEG during Induction of Anesthesia

异丙酚是快速、短效催眠药，对中枢神经系统抑制较轻。ＥＥＧ监测是判断异丙酚诱导期麻醉深度敏感而直接的手段。１８例ＡＳＡⅠ～Ⅱ级患者在注入芬太尼３．６μｇ／ｋｇ１０ｍｉｎ后给予异丙酚２ｍｇ／ｋｇ或硫喷妥钠４ｍｇ／ｋｇ于２０ｓ内缓慢静注，诱导期间用ＳＡＮ－Ｅｌ１Ａ７１脑电图监测仪持续描记脑电变化。结果表明，异丙酚与硫喷妥纳均首先产生β高幅兴奋性活动，最大效应期异丙酚无δ波，维持期效应则相似。起效时间、达到最大效应的时间无显著性差异，但异丙酚的作用时间明显短于硫喷妥钠。

8 ASA Ⅰ～Ⅱ patients were given either propofol(P) 2mg/kg or thiopentone(T) 4 mg/kg iv in 20s,10 minafter fentanyl 3.6 μg/kg iv(A). During inouction EEG was recorded with SAN-EI 1A71 electroencephalograph.Both P and T evoked an excited high amplitud β activity at first.Their EEG effects in maintenance of anesthesiawere also similar. But there were no δ waves found during the maximal effect of propofol. The onset time and thepeek time were not statistically different between group P and T,whereas the duration of maximal effect in groupP was significantly shorter than that in group T.