氟烷、安氟醚、七氟醚肝毒性与TXB_2、6－keto－PGF（1α）含量变化（氟烷性肝炎的研究Ⅲ）

Hepatotoxicity of Halothane,Enflurane and Sevoflurane and Change of TXB_2 and 6-keto-PGF1a

雄性ＳＤ大鼠饮用含苯巴比妥钠（１ｍｇ／ｍｌ）的饮水１周后，随机分为四组，每组８例，分别吸入：Ｃ，１４％Ｏ＿２／８６％Ｎ＿２；Ｅ，１４％Ｏ＿２／８６％Ｎ＿２／１．２ＭＡＣ安氟醚；Ｓ，１４％Ｏ＿２／８６％Ｎ＿２／１．２ＭＡＣ七氟醚；Ｈ，１４％Ｏ＿２／８６％Ｎ＿２／１．２ＭＡＣ氟烷１ｈ。２４ｈ后发现Ｈ组血浆ＡＬＴ活性显著高于其它各组，并有明显的小叶中心性肝细胞坏死及汇管区炎细胞浸润，血窦重度充血。Ｅ组可见部分肝小叶内有小叶中心性坏死及空泡变性。Ｈ组肝匀浆及血浆中ＴＸＢ＿２含量显著高于其它各组。６－ｋｅｔｏ－ＰＧＦ１ａ各组间均无显著差异。提示氟烷性肝炎与ＴＸＡ＿２／ＰＧＩ＿２平衡失调有一定的关系。

Male Sprague-Dawley rats were pretreated with phenobarbital and randomly divided into 4 groups, The ratswere exposed to O2/N2/1.2 MAC anesthetics for 1 hr and anesthetized by 14%O2/86%N2/(C), 14%O2/86%N2/1. 2MAC enflurane(E),14%O2/86%N2/1. 2MAC sevoflurane(S)and 14%O2/86%/N2/1. 2 MAC halothane(H)respectively. The livers of all rats given halothane had extensive centrilobular necrosis and denaturation. Accom-panying the morphologic damage was an increase in serum glutamic pyruvic transminase(ALT).The concentra-tions of TXB2 in plasma and the liver were significantly raised in group H(P< 0.01).With regard to 6-keto-PGF1a, no statistically significant difference was found in all groups.It is concluded that an imbalance of TXA2/PGI2 may be partly responsible for halothane hepatitis.