硬膜外氟哌啶或东莨菪碱减轻硬膜外吗啡镇痛期的恶心和呕吐

Epidural Droperidol or Scopolamine Attenuates Nausea and Vomiting during Postoperative Epidural Morphine Pain-relief

观察比较硬膜外氟哌啶或东莨菪碱减少硬膜外吗啡恶心、呕吐等副作用。结果：氟哌啶组（Ｍ＋Ｄｒ组，ｎ＝４０）恶心、呕吐和瘙痒发生率显著少于单纯吗啡对照组（Ｍ组，ｎ＝４０）。东莨菪碱组（Ｍ＋Ｓｃｏ组，ｎ＝４２）在恶心、呕吐方面与Ｍ组相比亦有显著区别。尿潴留和低血压，三组间比较无统计学差异。Ｍ＋Ｓｃｏ组口干发生率为７６．２％，其它两组无１例出现口干。三组镇静作用和镇痛作用时间比较均无显著性差异。未发现硬膜外氟哌啶或东莨菪碱的任何毒性反应。

he effect of epidural droperidol or scopolamine on reducing the side effects complicated by epidural morphinewas studied in 1 22 patients.The patients were devided into three groups,morphin-placebo(group-M,n=40),morphine-droperidol(group-M+Dr,n=40)and morphine-scopolamine(group+M+Sco,n=42).The resultsshow that incidence of nausea,vomiting and pruritus in group-M+Dr and group-M+Sco was less than that ingroup-M,The incidence of xerostomia in the group-M+Sco was 76.2%,which was not seen in both group-M andgroup-M+Dr,The compares three groups,No significant differences in urinary retention,hypotension,durationof analgesia and sedation were seen among three groups. Epidural droperidol or scopalamine did not result in anyappreciable toxicity.