加速度仪对小儿维库溴铵临床预注肌松效应的监测

Neuromuscular Blocker of Vencuronium with or without Priming in Humans

应用加速度仪四个成串刺激观察小儿维库溴铵（ＶＣＲ）预注法（ＰＰ）的肌松效应。４０例（ＡＳＡ１～Ⅱ）患者随机分成４组。小儿两组：Ⅰ组ＶＣＲＰＰ剂量４０％ＥＤ９５０．０２ｍｇ·ｋｇ（－１），插管（ＩＴ）剂量０．１ｍｇ·ｋｇ（－１）；Ⅱ组ＶＣＲ用非预注法（ＮＯ－ＰＰ）、ＩＴ剂量０．１２ｍｇ·ｋｇ（－１）。成人两组（对照）：Ⅲ组同Ⅰ组；醇Ⅳ组同Ⅱ组。结果：第Ⅰ、Ⅲ组（ＰＰ）肌松起效时间、高峰时间比第Ⅱ、Ⅳ组（ＮＯ－ＰＰ）明显缩短（Ｐ＜０．０５～０．０１）；小儿的无反应时间、高峰持续时间、２５％恢复期时间比成人组短。本研究为小儿选用非去极化类肌松药来加快气管插管提供了依据。

euromuscular function after vencuronium was monitored with Accelograph in both children(n=20)andaduIt patients(n=20).A priming dose(0. 02mg·kg(-1))of vencuronium followed by an intubation dose(0.1mg·kg(-1))of it was given in 10 children(group I)and 10 adults(group Ⅲ ),which was compared with another 10children(group Ⅱ)and 10 aduIts(group Ⅳ) in whom a bolus dose of vencuronium 0. 12mg· kg(-1) was adminis-tered. The resuIts: (l) The time of onset and peak effect was significantly shortened in group Ⅰ and Ⅲ in compar-ison with that in group Ⅱ and Ⅳ;(2)Neuromuscular blockade was accelerated with priming in both children andaduIts,(3)The time of no responsing, time of continous peak relaxation and time of 25%recovery were shortenedhchildren than in adults。