异搏定及硫酸镁预防气管插管所致心血管不良反应的临床研究

Clinical Effects of Verapamil and Magnesium Sulfate on Cardiovascular Responses during Tracheal Intubation

观察异搏定（５ｍｇ）或硫酸镁（６０ｍｇ／ｋｇ）缓解气管插管所致不良心血管反应的作用。结果表明，静脉注射异搏定５ｍｇ后快速诱导插管，麻醉诱导后动脉收缩压和舒张压均下降（Ｐ＜０．０５），气管插管后各时相动脉血压未升高，反而下降并有极显著性意义（Ｐ＜０．０１），插管后１ｍｉｎ心率增快（Ｐ＜０．０５）。静脉注射硫酸镁（６０ｍｇ／ｋｇ）后麻醉诱导插管，麻醉诱导后动脉收缩压及舒张压均下降（Ｐ＜０．０５），气管插管后各时相动脉收缩压与舒张压及心率均未升高（Ｐ＞０．０５）。

he effects of either magnesium sulfate 60mg/kg intravenously,or verapamil 5mg on cardiovascular responsesassociated with tracheal intubation were studied in 60 patients. Arterial systolic and diastolic pressure decreasedsignificantly after induction and at 1,5 and 10 minutes after intubation in the patients given verapamil(P<0.05),heart rate increased 1 minute after intubation. In the patients receiving magnesium sulfate,arterial systolic and dias-tolic pressures,and heart rate did not increase significantly.The systolic blood pressure decreased significantly 10min after intubation (P<0.05).The data show that,both verapamil and magnesium are effective in attenuatingcardiovascular responses to tracheal intubation.