免疫组化结合图像分析研究膀胱癌中表皮生长因子受体的分布及意义

Distribution and significance of EGFR on human bladder cancer by immunocytochemical and image analysis

应用免疫组化方法结合图像分析研究58例膀胱肿瘤表皮生长因子受体（EGFR）与膀胱肿瘤之间的关系。结果显示EGFR阳性率为34.5％,其阳性显色分别定位于细胞膜（占55％）和胞浆内（占 45％）。其阳性率在肿瘤的病理分级、临床分期及预后等方面差异显著（P<0.05）。提示EGFR的异常表达可作为判定膀胱肿瘤恶性程度及预后的一项重要指标。

In order to study the relationship between the epidermal growth factor receptor and bladder cancer ,the author used immunocy-tochemical and image analysis to detecte 58 of bladder cancer. The result show that the positive rate of EGFR is 34. 5% and localized in cellular mem-brance (55%) and cytoplasm(45%). The positive rate of EGFR makes significantly difference in pathological classification and clinical stage of carcinoma and prognosis ( P <0. 05). It is suggested that abnormal expression of EGFR is important datum for determinate invasiveness and prognosis of bladder cancer.