双氯灭痛与消炎痛治疗肾绞痛的比较

Comparative study of effect of diclofenac and indomethacin on renal colic

用随机对照单盲法,以临床上疗效肯定的消炎痛栓为对照,评定双氯灭痛直肠给药治疗肾绞痛152例的疗效。显示用自制双氯灭痛胶浆剂和双氯灭痛栓剂的总有效率分别为94.2％和91.8％,显效率为80.8％和77.6％。虽与对照组总有效率（82.4％）比较,差异无显著性（P>0.05）,但显效率均明显高于对照组（P<0.01,P<0.05）,且不良反应较少。双氯灭痛胶浆剂平均镇痛起效时间为11.1±6.1分钟,与栓剂组以及对照组比较,有极显著性差异（均 P<0.001）。认为双氯灭痛是目前治疗肾绞痛的理想药物,其胶浆剂经直肠给药,镇痛迅速有效,值得临床推广使用。

Effect of rectal diclofenac on renal colic was investigated in 152 cases by randomized .single blind tests with suppositoria indomethacin as control. The results showed that the total effective rates of diclofenas mucilloid and suppositoria diclofenac which were domestically prepared were 94. 2% and 91. 8% respectively.and they are slightly higher than that of the control (82. 4% . P>0. 05). But the remarkable improvement rates of the mucilloid and the suppositoria were significantly higher than that of the control(P<0. 01 ,P<0. 05)and the former had low sideeffects. The mean effect beginning time of the mucilloid(11. 1±6. 1min) was remarkedly shorter than that of the suppositoria and the control (P<0. 001). This study indicates that diclofenac is an effectual a-gent for renal colic .and its mucilloid,given through rectum,has a quick and efficacious analgesic action. It is worth applying in clinic treatment of renal colic.