皮层与穿通动脉脑梗塞患者血清脂蛋白及载脂蛋白A-I、B水平的研究

Serum lipoproteins,apolipoprotein A-I and B in cortical and perforating arterial infarctions

本文报告４２例皮层动脉脑梗塞（ＣＡＩ）、７０例穿通动脉脑梗塞（ＰＡＩ）与同龄健康对照组５１例的血脂、脂蛋白及载脂蛋白Ａ－Ｉ（ａｐｏＡ－Ｉ）、ａｐｏＢ含量的变化。结果显示：ＣＡＩＧ男女ＴＧ水平、ＴＣ／ＨＤＬ－ｃ比值、ＣＡＩＧ女ＬＤＬ－ｃ／ＨＤＬ－ｃ比值显著高于ＰＡＩＧ（Ｐ＜０．０５）；ＣＡＩＧ男女ＨＤＬ－ｃ、ＨＤＬｅ－ｃ、ａｐｏＡ－Ｉ水平及ａｐｏＡ－Ｉ／ａｐｏＢ比值显著低于ＰＡＩＧ（Ｐ＜０．００１～０．０５）。ＣＡＩＧ男女ＴＣ、ＨＤＬ３－ａ、ＬＤＬ－ｃ、ａｐｏＢ水平，ＣＡＩＧ男ＬＤＬ－ｃ／ＨＤＬ－ｃ比值与ＰＡＩＧ比较无显著差异（Ｐ＞０．０５）。ＣＡＩＧ、ＰＡＩＧ男女ＨＤＬ－ｃ、ａｐｏＡ－Ｉ／ａｐｏＢ显著低于对照组（Ｐ＜０．００１～０．０５），ＬＤＬ－ｃ、ａｐｏＢ、ＬＤＬ－ｃ／ＨＤＬ－ｃ显著高于对照组（Ｐ＜０．００１～０．０５）。ＰＡＩＧ伴高血压者显著多于ＣＡＩＧ（Ｐ＜０．０１）。本文提示：血清ＨＤＬ－ｃ、ａｐｏＡ－Ｉ／ａｐｏＢ降低，ＬＤＬ－ｃ、ａｐｏＢ、ＬＤＬ－ｃ／ＨＤＬ－ｃ升高是ＣＡＩＧ、ＰＡＩＧ共同的危险因素；ＨＤＬ－ｃ、ＨＤＬ２－ｃ、ａｐｏＡ－Ｉ、ａｐｏＡ－Ｉ／ａｐｏＢ降低，ＴＧ、ＴＣ／ＨＤＬ－ｃ升高对?

AbstractSerum lipoproteins and apolipoprotein A-I and B were investigated and analvzed in 4 2patients with cortical arterial infarctions(CAI),70 patients with perforating arterial infarctions(PAI)and 51 normal controls. The results showed that TG Ievel,TC/HDL-c ratio were higher in CAIG(both male and female)than in PAIG(P<0.05),the HDL-c,HDL2-c,apo A-I levels and apo A-I/apo B ratio were much lower in CAIG than in PAIG (P<0. 001～0.05),the LDL-c/ HDL-c ratio was significantly higher only in female CAIG when compared with PAIG(P< 0.05).The TC,HDL3-c,apoB levels(both male and female),LDL-c/HDL-c ratio(only male)did not show any significantly difference between CAIG and PAIG(P>0.05).The occurrence rate of accompanying hypertension was significantly higher in PAIG patients than CALG(P<0.00 1).These results suggest that in comparison with the controls the lower values of the H DL-c and apoA-I/apoB ratio and the higher LDL-c,apoB levels and LDL-c/ H DL-c ratio are common risk factors for CAIG and PAIG. Morever,we inferred that the higher TG Ievel,TC/HDL-c ratio were more useful indices for patients with CAI than PAI.The main risk factor of PAI is hypertension.