梗阻性黄疸与消化性溃疡

Frequency of Gastroduodenal Uicerations in Patients with Obstructive Jaundice

研究234例梗阻性黄疸和209例非黄疸病人的消化性溃疡发病情况.结果黄疸组42例(17.9%),而对照组仅5例(2.4%)发现胃或十二指肠溃疡.十二指肠溃疡发病率两组有显著差别,而胃溃疡则两组发生率无明显差别.黄疸持续的时间对溃疡的发生无明显影响.胆总管阻塞者溃疡发生率高,而胆总管以上部位阻塞者溃疡发生率与对照组无明显差异.本研究进一步证实了胃酸在十二指肠溃疡形成中的重要作用.

We have studied the frequency of gastric and duodenal ulcerations in 234 with jaundice patients, compared with 209 patients without jaundice. Each pa-tient underwent endoscopy, with careful examination of the stomach and duodenum. Ulcerations were seen in 42 patients with jaundice (17. 9%) and in only 5 patients without jaundice (2. 4%). The difference was significant for duodenal ulcerations but not for gastric ulcerations. There was no significant difference in the influence on the frequency of ulcerations of duration of the jaundice. Ulcerations were more frequent in the case of obstruction of the common bile duct than in other etiologies. This study confirmed the hypothesis of hypergastric acid playing an important role in the patho- genesis of peptic ulcerations.