慢性肝病与乙型、丙型肝炎病毒感染关系的探讨

A Study of Relationship Between Chronic Liver Disease and HBV HCV

采用ELISA法对25例慢性肝炎,105例肝硬化,64例肝癌以及8例急性黄疸型肝炎进行了HBV标志物及抗-HCV的检测.结果:HBV感染率为80.6%,抗-HCV检测阳性率为46%,二者均阳性的双重感染率为32%.其中肝癌组双重感染明显高于肝硬化组P<0.001.单纯抗-HCV检出率为10.8%,说明HBV是引起肝炎、肝硬化、肝癌的主要病因,而HCV感染也是致病因素.对有输血史的慢性肝炎、肝硬化、肝癌100例进行抗-HCV检测,其阳性率59%,而102例无输血史的肝病患者抗-HCV检出率为25%,输血组抗HCV检出率明显高于无输血组P<0.001.其中慢性肝炎、肝硬化、肝癌病人输血组抗-HCV检出率亦明显高于无输血组,各组P<0.001.故提示:HCV感染与输血有密切关系.50例HBV标志物阴性的健康献血员抗-HCV阳性率为6%.

HBV-marker anti-HCV are tested in 25 cases of chronic hepatitis 105 cases hepatic cirrhosis 64 cases of hepatic carcinoma 8 cases of acute jaundice hepatitis with ELISA method in this report. The result shows that 80. 6% of all the cases is HBV-marker positive, 87% is anti-HCV positive and 32% are super infection. The rate of super infection in the group of primary hepatic carcinoma is much higher than that in the group of liver cirrhosis (P<0. 001). Only 10. 8% is pure-anti-HCV posi-tive. So the main cause of hepatitis, hepatic cirrhosis, hepatic carcinoma, and infec-tion of HCV is also an important cause. In the dection of 100 cases with blood trans-fusion in the patients of chronic hepatitis, hepatic cirrhosis, hepatic carcinoma, 59% is anti-HCV positive. While in 102 cases of liver disease with no blood transfusion on-ly 25% is anti-HCV positive. The positive rate of anti-HCV in the group of chronic hepatitis, cirrhosis of liver and primary hepatic carcinoma with blood transfusion is much higher than in the group of no blood transfusion (P<0. 001). That shows these is close relation between HCV infection and blood transfusion. The detectivity of anti-HCV in 50 healthy donors with negative HBV-marker is 6%.