胃十二指肠疾病与血浆激素关系的初步研究

Research of Plasma Gastrointestinal Hormone in Gastric and Duodenal Disease

对64例胃十二指肠疾病患者(包括慢性残表性胃炎23例,萎缩性胃炎5例,胃溃疡10例,十二指肠溃疡14例及胃癌12例)的血浆生长抑索(SS)、血管活性肠肽(VIP)、胃动素(MTL)及血清胃泌素(Gas)的研究表明,血浆SS水平在胃十二指肠溃疡组及胃癌组均低于正常对照组(P<0.001);血浆VIP浓度在胃溃疡时升高最明显,与正常组及各疾病组比较均有显著性差异(P<0.01);十二指肠溃疡及胃癌组的血浆MTL含量均高于正常对照组(P<0.05);血清Gas水平在浅表性胃炎和萎缩性胃炎时均高于正常对照组(P<0.01).

Plasma levels of vasoactive intestinal peptide (VIP), somatostatin (SS), motilin(MTL) and gastrin(Gas) in 64 patients with gastric and duodenal dis-eases and 36 healthy controls were measured by radioimmunoassay. Of 64 patients, 23 had chronic superficial gastritis(CSG), 5 chronic atrophic gastritis(CAG) , 10 gas-tric ulcer (GU), 14 duodenal ulcer (DU) and 10 gastric cancer (GC). The results showed: Plasma levels of SS in GU, DU and GC were lower than those in healthy controls (P<0. 001). Plasma concentrations of VIP in GU were highest in all groups, there were significant differences of VIP levels between GU and any other groups (P <0. 01). As compared to controls, higher plasma levels of MTL in DU and GC (P< 0. 05) , elevated serum Gas in CSG and CAS (P<0. 01) were found.