静脉注射三磷酸腺苷的瞬间致心律失常作用和安全性

Safety and proarrhythmia of intravenous adenosine triphosphate

给７９例阵发性室上性心动过速患者分级递增快速静注三磷酸腺苷（ＡＴＰ）３３２次，诱发缓慢心律失常（窦性心动过缓和１°～２°房室阻滞）１３５例次，占４０．７％；快速心律失常（窦性心动过速、房性反复心搏、室上性心动过速、阵发性心房颤动、房性和室性早搏）２５４例次，占７６．５％。除室上性心动过速外，均为一过性心律失常，皆无明显的血流动力学障碍。

A total of 332 tests of intravenous bolus adenosine triphosphate(ATP) were performed during sinus rhythm or/and inducible supraventricular tachycar-dia (SVT) in 79 patients with paroxysmal supraventricular tachycardia. It was foundthat ATP induced 33 times (9. 9% ) of sinus bradycardia , 67 times (20. 2% ) of first-de-gree AV block (AVB), 20 times (6%) of second-degree type I AVB, 15 times(4. 5%) of second-degree type AVB, 194 times (58. 4%) of sinus tachycardia, 34times (10. 2%) of atrial reciprocal beats. 13 times (3. 9) of SVT, 8 times (2. 4%) ofoccasional atrial premature beats . 3 times(0. 9%) of paroxysmal atrial fibrillation and 2times (0. 6%) of occasional ventricular premature beats. All arrhythmias induced byATP were temporary except SVT and did not cause hemodynamic disturbance.