高原移居及世居汉族高血压病遗传度研究

Studies on hypertension heritability between immigrants and natives of Han population at high altitude

对移居及世居高原的汉族高血压患者一级亲属进行调查，根据Ｆａｌｃｏｎｅｒ估计阈值性状遗传度公式，分别计算了遗传度。结果表明：移居高原的汉族人群高血压病遗传度较世居者高，为６６．８％；而世居者分别为３３．２％和３５．０％。提示：长期在低压低氧环境下，高血压病的累加基因对其性状的贡献相对变小。

Abstract The first degree relatives to immigrants and natives of Han population with primary hypertension at high altitude were investigated by Falconer formula, and hypertension heritabilities were calculated.The results indicated:①the heritability of immigrants (66.8%)was higher than those of natives;②the heritability of natives(33.2%and 35.0%)were lower.It suggests that accumulated genes of those with hypertension contribute lesser to the phenotypes because of living at high altitude for a long time.