维生素K依赖性凝血因子检测及临床意义

Clinical Value of Detection of Vitamin K-Dependent Coagulation Factor

测定了临床几种疾病状态下6种依赖维生素K凝血因子的含量。证实肝、胆疾病长期联合使用抗生素,采用VK拮抗剂治疗及DIC时可引起继发性依K因子减少,VK治疗有效;而某些血栓症则由于先天性蛋白C、S缺乏所致,VK治疗无效。

This paper presents the activity detection of the six viatmin K-dependent coagulant factors when vitamin K deficiency exists clinicaily. It is verified that the vitamin K treatment is effective as the decrease of vitamin K-dependent factors is caused by liver and gall bladder diseases, long-term compound antibiotics usage, vitamin K-antagonist treatment or DIG but ineffective to thromboembolism caused by congenital protein C & S deficiency.