急性白血病患者血清甲状腺激素的研究

Study of Serum Thyroid Hormones in Patients with Acute Leukemia

本文对43例急性白血病患者初发、完全缓解(CR)、复发时的血清甲状腺激素进行了检测。结果:初发、复发的患者血清TT_3明显低于正常对照组(P值分别<0.01、0.001),而TT_4、FT_4I及TSH无显著性改变;复发组rT_3高于正常值。在CR期,所有指标接近正常(P>0.05)。这种不伴TSH升高的低T_3可能即为病态甲状腺综合征中的低T_3综合征。低T_3综合征与疾病分期有关,并与Karnofsky健康状况相关。我们认为该综合征是疾病时的一种保护机制,建议低T_3综合征可作为急性白血病分期的参考。

The serum thyroid hormones were measured in 43 patients with acute leukemia at the onsec、omplete remission (CR) and relapse. Results showed that serum total T3 in patients at the onset or at the relapse was lower than that in normal subjects (P<0. 01、0. 001 respectively), while the TT4、FT4I and TSH in the patients had no significant difference with the control. rT3 at relapse of the disease was higher than the normal value (P<0. 05). In CR patients,all the hormones lever was near normal (P>0. 05). Lowered T3 without rised TSH in the patients probably was low. T3 syndrome which is one form of ESS ( Euthyroid Sick Syndrome). Relationship between low-T3 sydrome and stages of acute leukemia was observed. It was demonstrated that the low-T3 syndrome correlated with general health conditions by Karnofsky. It was believed that low-T3 sydrome was a protective adaptation in the disease. We suggested low-T3 sydrome in 'acute leukemia might helps in staging of the disease.