微量肝素治疗播散性血管内凝血的临床研究

The Clinical Investigation of Mini-dose Heparin Administration in Patients with Disseminated Intravascular Coagulation

本文报道52例各种疾病合并DIC,应用微量肝素,6～25mg(750U～3125U/)d静滴,40例有效,有效率76.9％。常规肝素量治疗组48例,12500U～25000U/d静滴,有效14例,有效率29.2％(P<0.01),无肝素治疗组30例,7例有效,有效率23.3％(P<0.01)。观察结果表明:微量肝素治疗DIC疗效高,应用方便,副作用小。

In this paper the clinical observation of mini-does heparin admini-stration(750-3125 units or 6-25 mg daily) by intravenous infusion in 52 cases of disseminated intravascular coagulation (DIC) from various kinds of internal diseases was reported. The results showed 40 cases (76. 9%) were effected. In comparison with the investigated group, another group (48 cases) treated with conventional dosage of heparin infusion (12 500-25 000 units i. v. daily) and a contol group treated with conventional medical therapy without heparin administration(30 cases) were observed,14 cases(29. 2%) and 7 cases(23. 3%) were effective respectively (P value <0. 01 in both groups). It proved that the mini-dose heparin therapy in DIC revealed a higher efficacy in comparison with the other two groups and it was easier to be practised in clinical administration with less side reactions.