应用COX模型判断慢性粒细胞白血病患者的预后

Prognostic Evaluation of the Patients with Chronic Myelogenous Leukemia Using Cox Model Analysis

应用国际慢性粒细胞白血病(CML)预后研究协作组建立的Cox模型对35例CML患者进行了回顾性分析,高危患者占80％,3年生存率35.7％,中危患者占20％,生存期均超过3年,无1例低危组,提示该模型在我国也有一定的实用价值。在判断CML预后的几个危险因素中,脾脏大小是最重要的,红细胞压积对46岁以下患者预后影响也较大。外周血中原始细胞百分数及血小板计数在高中危组之间差异并不显著。

Thirty-five patients with chronic myelogenous leukemia (CML) were analysed retrospectively using the Cox model developed by International CML Prognostic Study Group. There were 28 cases(80%) in the higher-risk group and 7 cases (20%) in the intermediate group. The 3-year survival rates for the two groups were 35. 7% and 100%, respectively. There was none in the lower-risk group. It is suggested that the Cox prognostic model should have certain practical evaluation in our population. Spleen size was the most important among the several visky facfors which had prognostic significance. Hematorit became more significant in the younger population who aged less than 46 years. There were not any significant differences in percent of circulating blasts and platelet count between the higher-risk and intermediate groups.