骨髓增生异常综合征骨髓活检的临床意义和预后价值

The Clinical Significance and Prognostic Evaluation of Bone Marrow Biopsy in Myelodysplastic Syndromes

本文对82例初诊的骨髓增生异常综合征(MDS)进行骨髓活检,分析组织学特征与临床的关系。研究表明:未成熟前体细胞异常定位(ALIP)、原红细胞小岛、异形巨核细胞和红细胞是MDS的主要组织学特征,并伴有骨髓基质成分的病理改变。同时,对骨髓造血组织增生程度的判断有重要的预后价值,增生愈活跃,预后愈差。

In this paper,bone marrow biopsy from 82 patients with an initial diagnosis of myelodysplasdtic syndomes (MDS) were examined the relationship between histological findings and clinical features. The results indicated that main his-tological features were abnormal iocalization of immature precursors,island of ery-throblasts,morphological abnormalities in erythroid and megakaryocytic lineages in MDS,and accompanied pathological changes of bone marrow stromal constituents. Meanwhile, the classification according to bone marrow cellularity has important prognostic evaluation. The hisher the degree of marrow cellularity became,the poorer the prognosis.