肺癌组织中神经内分泌细胞的临床病理意义

Clinical Pathological Significance of Neuroendocrine Cells in Lung Carcinomas

用NSE和嗜铬颗粒素抗体对40例不同类型肺癌做了免疫组化染色,以观察其与各种肺癌的分化,间质纤维组织,淋巴细胞及核分裂象的关系。40例肺癌中鳞癌21例,腺癌10例,小细胞癌7例,类癌2例,发现鳞癌中NSE和嗜铬颗粒素阳性率均为76.2％,而且多分布于中一高分化,间质纤维组织多,淋巴细胞多和核分裂象少的区域。腺癌的NSE阳性率为60％,嗜铬颗粒素阳性率为30％,多分布于低分化区,与间质纤维组织和淋巴细胞关系不密切。小细胞癌和类癌的NSE和嗜铬颗粒素均为阳性。结果可见NSE和嗜铬颗粒素在肺鳞癌的分化分级中有其参考意义,是否对预后有意义有待进一步追随病例证实。

In order to study the relationship between NSE. Chromogranin antigens and the differentiation, interstitical fiber tissue reaction, the lymphocyte infiltration and the phenomenon of karyokinesis, we performed the immunohistochemistry staining of NSE and Chromogranin of 40 cases suffered from differen kinds of carcinomas of lung. Among the 40 cases, 21 cases suffered from squamous cell carcinoma; and 2, carcinoid, The result showed that the positive rate of NSE and Chromograin in squa-mous cell carcinoma was 76. 2%, and mainly distributed among the carcinoma tissue are as of well-differentiated, rich in inter- stitical fiber tissue and lymphocyte infiltration and karyokinesis. The positive rate of chromogranin was 30% in adenocarcino-mas, they distributed mainly among the poor differentiated area and had less relationship with the interstitical fiber tissue reaction and lymphocyte infiltration. the significance of NSE and chromogranin in the diffnentiation of squamoas cell carcinoma of lung is an important phenomenon in the pathology of lung cancer, Its prognostic significance would be researched in the next.