氨甲喋呤治疗输卵管妊娠8例

THE TREATMENT OF 8 CASES OF TUBAL PREGNANCY WITH AMETHOPTERIN

对氨甲喋呤治疗早期输卵管妊娠的探讨。结果表明，对停经时间＜８周，Ｂ超输卵管直经＜３～４ｃｍ，腹腔内出血不多，病人生命体征无改变，无肝、肾功能障碍及出血疾患的病人采用氨甲喋呤２０ｍｇ肌肉注射，每日一次，５天为一疗程。测血β—ｈｃＧ及Ｂ超了解治疗效果，一疗程后胎囊明显缩小，胚芽消失，β─ｈｃＧ迅速下降，临床症状消失，唯包块消失时间较长。氨甲喋呤为抗叶酸类抗肿瘤药物，因其抑制细胞的分裂增殖，可杀灭滋养细胞。氨甲喋呤肌肉注射治疗早期输卵管妊娠效果可靠，副作用小，用药方便，可以门诊治疗。

This article reports our treatment of early tubal pregnancy with amethopterin. We gave intrainuscular injections, 20mg daily, 5 days as a course of treatment,to those patients who had experienced an intermenstrual period of less than eight weeks,with their oviduct diameter of less than 3cm to 4cm,not much bleeding in the abdominal cavity,no changes of physical signs nor hepatic and kidney dysfunction and no hemorrhagic diseases. The blood test of β-hcG value and B- ultrasonic check -up showed that after the first course of treatment,the fetal shrank apparently,the fetus disappeared,the β- hcG value decreased rapidly and the clinical symptoms vanished. However, the lump would not disappear until an extended period of time had passed,Amethopterin is an antifolic and antineoplastic agent which kills the trophocytes by preventing the division and proliferation of cells. The treatment of early tubal pregnancy with amethopterin intramuscular injection has proved to be reliable for its less side effects,easy application of medicine and convellient treatment in the outpatient department.