缺锌对血浆─氧化氮及部分免疫指标的影响

A Study of the Effects of Zinc Deficiency on a Cellular Factor of Plasma Ni-trogen Monoxide in Rats

通过缺锌大鼠模型观察缺锌对血浆一氧化氮（ＮＯ）的变化，并探讨ＮＯ与血清锌，以及部分免疫指标的关系。结果表明：（１）缺锌（ＺＤ）组血浆ＮＯ、肿瘤坏死因子（ＴＮＦ）、骨髓和脾脏细胞增殖指数（ＰＩ）、腹腔吞噬细胞吞噬率、吞噬指数和外周血粒细胞杀菌力均非常显著低于配对（ＰＦ）组和自由喂养（ＡＬ）组。（２）血浆ＮＯ与血清锌呈显著正相关。ＺＤ组ＮＯ与血浆ＴＮＦ、脾淋巴细胞ＰＩ正相关。ＰＦ组ＮＯ与吞噬细胞吞噬率、吞噬指数、外周血粒细胞杀菌力呈正相关。

The changes of plasma nitrogen monoxide(NO)during zinc deficiency(ZD)Were obeerved in rats and therelationship between plasma NO and serum zinc and several immune indices Was investigated.It Was found that the plas-ma level of NO and tumor necrosis factor(TNF).the proliferative index of bone marrow and splenic cells.the pagocyticrate and index of abdominal phagocytes and the bacteriocidal activity of peripheral granulocytes were significantly lowetin ZD group than in pair-fed and adequate libitum groups. The plasma N was positively correlated with serum zinc. Inthe ZD group.plasma NO was positively correlated with plasma TNF and the proliferative index of splenic cell.in thepair-fed group.plasma NO、was positively correlated with the phagocytic rate and index of abdominal phagocytes and thebecteriocidal activity of peripheral gran ulocytes.