摘要
在ｐＨ为２．５的氯乙酸－氯乙酸钠缓冲液中，在加热条件下，偏钒酸铵迅速氧化异丙嗪（又名非那根），得到一种樱红色产物，波长λ＿ｍａｘ＝５２０ｎｍ，而且异丙嗪的异构物氯丙嗪（又名冬眠宁）允许量较大。据此，本文提出了一个选择性较好的分光光度法，用以测定药物中异丙嗪含量，其浓度在２～１０ｍｇ／Ｌ范围内符合比尔定律，检出限为０．８ｍｇ／Ｌ。
A simple spectrophotometric method for the determination of Promethazine inpharmaceutical preparations is described.The method is based on the oxidation ofpromethazine with Ammonium metavanadate in pH2.5 solution,then the absorbance ofcoloured compound was measured at 520 nm,The method is applied to the determination ofpromethazine hydrochloride in drugs. It is quick,and sensitive enough.
出处
《南昌大学学报（理科版）》
CAS
1994年第3期313-316,共4页
Journal of Nanchang University(Natural Science)
关键词
盐酸异丙嗪
偏钒酸铵
分光光度法
promethazine,ammonium metavanadate,spectrophotometry
