汉防己甲素对家兔实验性前色素膜炎的抑制作用

Inhibitory Effects of Tetrandrine on Experimental Anterior Uveitis in Rabbits

汉防己甲素（Ｔｅｔ）５Ｏｍｇ／ｋｇ ｉｐ，能显著抑制晶体蛋白引起的家兔前色素膜炎的发生，降低虹膜中前列腺素Ｅ总量，抑制白细胞的渗出。病理学检查发现虹膜的炎症反应明显较对照组为轻。Ｔｅｔ的抗前色素膜炎的机理可能与其降低细胞内钙水平，抑制炎症介质的生成有关。

Anterior uveitis was induced by injection of lens protein into anterior chamber of rabbit eye. Tetrandrine(Tet) (50 mg/kg ip) showed marked inhibition on this ocular inflammation, the total content of prostaglandin E in irises, and leukocyte chemotaxis. The pathological examination revealed that infiammation of irises in Tet group was lighter than that in control group.The antiinflammatory mechanism of Tet may be relatcd to reduction of intracellular free calcium and inhibition of synthesis of inflammatory factor.