转铁蛋白表现型与习惯性流产、急性白血病及慢性乙型肝炎的相关研究

Relationship Between Phenotypes of Transferrin C and Habitual Abortion, Acute Leukemia and Chronic Hepatitis B

应用等电聚焦电泳及免疫固定技术,调查了南京地区习惯性流产妇女64例,急性白血病63例,慢性乙型肝炎51例。检测其转铁蛋白表现型分布及基因频率,并与相应对照组比较,发现了T_1C^2基因频率在习惯性流产组呈显著性增加(P<0.05),T_1C^2-2型人群疾病相对危险率3.1。其它两组无显著性差异(P>0.05)。

Using Isoelectric focusing electrophoresis followed by immunofixation, the distribution of phenotypes of Transferrin C was investigated in 64 patients with habitual abortion, 63 with acute leukemia and 51 with chronic hepatitis B in Nanjing. The allele frequency for TfC2 in patients with habitual abortion was significantly increased than that of the controls(P<0.05). The relative risk for habitual abortion in the TfC 2-2 population was 3.1. As for the distribution of TfC phenotypes no Noteworthy deviation was observed between the controls and the patients with other groups (P>0.05).