小儿肺炎与血小板活化因子

With Plasma Platelet-activating Factor in Childten

应用生物化学方法测定了４０例小儿肺炎血浆血小板活化因子（ＰＡＦ），结果急性期患儿血ＰＡＦ为５．０８±１．０２ｍｇ／Ｌ，明显高于正常对照组（１．４５±０．７９ｍｇ／Ｌ），恢复期时为１．１１±０．３８ｍｇ／Ｌ，已降至正常。本研究还发现伴有喘鸣的肺炎患儿血浆ＰＡＦ值较普通型肺炎患儿高，血白细胞总数与皿浆ＰＡＦ呈正相关。说明ＰＡＰ不仅是一种过敏介质，更是一种炎症介质。作者推测肺内产生较低量ＰＡＦ可导致肺内非特异性炎症，产生较高量时则引发气道高反应性，结果提示抗炎或抗ＰＡＰ是治疗肺部炎症疾病的基础。

Plasma platelet-activating factor(PAF)of 40 children with pneumonia wasdetermined with bioassay.Data showed the level of plasma PAF was 5.08±1.02mg/L in patients at acute period,higher than that of normal control(1.45±0.79mg/L),and decreased to normal value(1.11±0.38mg/L) at convalescence period.In this study it was aiso found that the plasma PAF concentration of patients with wheezing was higher than that of patients with common type of pneumonia,There was positive correlation between the number of blood leukocyte and the level of plasma PAF.This study indieated that PAF was not only a allergic mediator but also an inflammation mediator.The authors hypothesized that relatively low production of PAF in lung mediated non-specific uiflammation in lung but comparatively high production caused airway hyper-reactivity.Therefore,these res ults suggested that anti-inflammation and anti-PAF could be the principal bases for treatment of inflammatory diseases in lung.