摘要
银耳孢糖在体外能明显促进ＬＰＳ对小鼠脾细胞的增殖反应，药物本身对脾细胞具有丝裂原作用，能明显增强ＮＫ细胞和ＡＤＣＣ活性。浓度为２５～２５０μｇ／ｍｌ时，能提高ＣｏｎＡ诱导脾细胞产生ＩＬ－２；当浓度大于２５μｇ／ｍｌ时，它可抑制ＣｏｎＡ诱导的Ｔ淋巴细胞增殖反应及胸腺细胞￣３Ｈ－ＴｄＲ自发掺入率，抑制程度随药量增加而更明显。
TSP could markedly enhance the proliferative response of the murine splenocyte to LPS and induce the mitogenesis of the spleen cells.Furthermore,it was able to augment the activity of natural killer cell and ADCC;at a dosage of 25～250μg/ml,the ability of splenocytes to produce IL-2 induced by ConA had been improved;at the concentration of 250μg/ml or more,TSP could inhibit the proliferative response of the murine lymphocyte to ConA and the 3H-TdR spontaneous incorporation rate of thymocytes,and the inhibitory action ran in paralell with the increase in concentration of TSP.
关键词
银耳孢糖
抗肿瘤作用
免疫细胞
tremella fuciformis spores polysaccharides
lymphocyte transformation
natural killer cell
antibody-dependent cell-mediated cytotoxicity
interleukin 2
thymocytes
spontaneous incorporation
